' 
![]()
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.7
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin reduces glioma tumor growth
Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies.
Directly studies curcumin efficacy
We conducted a thorough investigation into how curcumin, a compound found in turmeric, affects brain tumors, particularly gliomas. Our research involved a systematic review and meta-analysis of 24 studies from 15 different articles. Each study utilized murine xenograft models to observe the effects of curcumin on tumor growth.
Through our analysis, we discovered that curcumin significantly reduced tumor volume compared to control groups. The overall results showed a notable decrease, with a standardized mean difference of -2.079, suggesting a strong therapeutic effect.
We explored various conditions under which curcumin was tested, including different animal models and administration methods. While we did identify some publication bias in the existing studies, this did not negate the effectiveness of curcumin. Overall, our findings strongly advocate for further research into curcumin as a potential treatment for gliomas.
Through our analysis, we discovered that curcumin significantly reduced tumor volume compared to control groups. The overall results showed a notable decrease, with a standardized mean difference of -2.079, suggesting a strong therapeutic effect.
We explored various conditions under which curcumin was tested, including different animal models and administration methods. While we did identify some publication bias in the existing studies, this did not negate the effectiveness of curcumin. Overall, our findings strongly advocate for further research into curcumin as a potential treatment for gliomas.
Read More
8
Tetrahydrocurcumin shows promise against glioblastoma
Synthesis, Cytotoxicity, and Mechanistic Evaluation of Tetrahydrocurcumin-Amino Acid Conjugates as LAT1-Targeting Anticancer Agents in C6 Glioma Cells.
Moderate relevance to turmeric effects.
We explored the potential of a turmeric derivative known as tetrahydrocurcumin (THC) in combating glioblastoma, a highly aggressive brain cancer. While THC on its own has shown promise, we aimed to enhance its effectiveness by modifying it to target a specific protein called LAT1, which plays a crucial role in how cancer cells acquire nutrients.
To test this, we synthesized a series of THC-amino acid conjugates, combining THC with several amino acids, like phenylalanine, in hopes of boosting its anticancer properties. Among these, THC conjugated with two phenylalanines stood out, demonstrating significantly increased toxicity towards glioma cells compared to THC alone. Specifically, we found that this compound not only killed more cancer cells, but also inhibited their growth and spread more effectively.
Interestingly, when we paired this modified THC with an LAT1 inhibitor, we observed even greater effects, leading to an increase in cellular death. This compound's mechanism involved shutting down cell-signaling pathways important for cancer cell survival. Overall, our findings suggest that THC, especially when modified, could serve as a promising option for treating brain tumors like glioblastoma, opening new avenues for therapeutic development.
To test this, we synthesized a series of THC-amino acid conjugates, combining THC with several amino acids, like phenylalanine, in hopes of boosting its anticancer properties. Among these, THC conjugated with two phenylalanines stood out, demonstrating significantly increased toxicity towards glioma cells compared to THC alone. Specifically, we found that this compound not only killed more cancer cells, but also inhibited their growth and spread more effectively.
Interestingly, when we paired this modified THC with an LAT1 inhibitor, we observed even greater effects, leading to an increase in cellular death. This compound's mechanism involved shutting down cell-signaling pathways important for cancer cell survival. Overall, our findings suggest that THC, especially when modified, could serve as a promising option for treating brain tumors like glioblastoma, opening new avenues for therapeutic development.
Read More
8
Insights on turmeric for brain tumors
Indian Ayurvedic medicine: Overview and application to brain cancer.
Moderate relevance to turmeric's effects
We looked into how turmeric might impact brain tumors, particularly through its key component, curcumin. The research gathered various studies that shed light on its potential benefits in fighting cancer.
In recent years, scientists have been keen on exploring turmeric's anti-cancer properties. They found that curcumin may help reduce cell growth in brain tumor cells, encourage apoptosis (or programmed cell death), and even inhibit certain pathways significant to cancer progression.
However, it’s essential to note that while initial findings show promise, more extensive testing in clinical trials is needed to truly understand turmeric’s effectiveness against brain tumors. Early results are encouraging, but we are still gathering evidence before we can confirm significant benefits.
Overall, it appears that turmeric, particularly through curcumin, may offer some anti-cancer activity against brain tumors. Yet, we must continue exploring its effects in more controlled settings to validate these observations.
In recent years, scientists have been keen on exploring turmeric's anti-cancer properties. They found that curcumin may help reduce cell growth in brain tumor cells, encourage apoptosis (or programmed cell death), and even inhibit certain pathways significant to cancer progression.
However, it’s essential to note that while initial findings show promise, more extensive testing in clinical trials is needed to truly understand turmeric’s effectiveness against brain tumors. Early results are encouraging, but we are still gathering evidence before we can confirm significant benefits.
Overall, it appears that turmeric, particularly through curcumin, may offer some anti-cancer activity against brain tumors. Yet, we must continue exploring its effects in more controlled settings to validate these observations.
Read More
Most Useful Reviews
9.5
Effective treatment
I have been taking 2 gms (four capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I entered remission within three months, and all tumours have disappeared. I have now been in remission with no evidence of disease for eight months.
Read More
9.5
Protects brain
This curcumin is one of the few effective supplements recommended for children with autism to alleviate neuroinflammation. It offers high purity and is safe for children. Curcumin’s anti-inflammatory effect is beneficial in protecting the brain from degenerative processes.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.1
9
Curcumin boosts glioblastoma treatment
The Synergistic Combination of Curcumin and Polydatin Improves Temozolomide Efficacy on Glioblastoma Cells.
Limited relevance to turmeric alone
We explored the potential of combining curcumin, a natural compound from turmeric, with polydatin to enhance the effectiveness of temozolomide (TMZ) in fighting glioblastoma, a highly aggressive brain tumor. The study examined how this combination can boost the anti-cancer properties of TMZ, a standard chemotherapy used in treating glioblastoma.
Our approach involved pretreating glioblastoma cells with curcumin and polydatin before applying TMZ. We observed that this synergistic combination significantly improved the treatment response. The natural compounds appeared to enhance cell survival, differentiation, and reduce tumor invasiveness, which is particularly important given the high rates of TMZ resistance in glioblastoma patients.
Through various laboratory techniques, including cell viability tests and protein expression analysis, we gathered compelling evidence suggesting that curcumin, alongside polydatin, notably increases the effectiveness of temozolomide on drug-resistant glioblastoma cells. These findings encourage further investigation into the use of natural compounds in cancer treatments, highlighting the potential for integrated therapy approaches.
Our approach involved pretreating glioblastoma cells with curcumin and polydatin before applying TMZ. We observed that this synergistic combination significantly improved the treatment response. The natural compounds appeared to enhance cell survival, differentiation, and reduce tumor invasiveness, which is particularly important given the high rates of TMZ resistance in glioblastoma patients.
Through various laboratory techniques, including cell viability tests and protein expression analysis, we gathered compelling evidence suggesting that curcumin, alongside polydatin, notably increases the effectiveness of temozolomide on drug-resistant glioblastoma cells. These findings encourage further investigation into the use of natural compounds in cancer treatments, highlighting the potential for integrated therapy approaches.
Read More
9
Curcumin reduces glioma tumor growth
Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analysis of Animal Model Studies.
Directly studies curcumin efficacy
We conducted a thorough investigation into how curcumin, a compound found in turmeric, affects brain tumors, particularly gliomas. Our research involved a systematic review and meta-analysis of 24 studies from 15 different articles. Each study utilized murine xenograft models to observe the effects of curcumin on tumor growth.
Through our analysis, we discovered that curcumin significantly reduced tumor volume compared to control groups. The overall results showed a notable decrease, with a standardized mean difference of -2.079, suggesting a strong therapeutic effect.
We explored various conditions under which curcumin was tested, including different animal models and administration methods. While we did identify some publication bias in the existing studies, this did not negate the effectiveness of curcumin. Overall, our findings strongly advocate for further research into curcumin as a potential treatment for gliomas.
Through our analysis, we discovered that curcumin significantly reduced tumor volume compared to control groups. The overall results showed a notable decrease, with a standardized mean difference of -2.079, suggesting a strong therapeutic effect.
We explored various conditions under which curcumin was tested, including different animal models and administration methods. While we did identify some publication bias in the existing studies, this did not negate the effectiveness of curcumin. Overall, our findings strongly advocate for further research into curcumin as a potential treatment for gliomas.
Read More
9
Curcumin shows promise against GBM
Curcumin combining temozolomide formed localized nanogel for inhibition of postsurgical chemoresistant glioblastoma.
Combination therapy explored
We explored the use of a special treatment approach for tackling temozolomide (TMZ)-resistant glioblastoma (GBM), a type of brain tumor known for being hard to treat. This involved encapsulating curcumin—a powerful compound from turmeric—along with TMZ in nanoparticles. These nanoparticles were further combined into a thermosensitive gel that could be injected right into the area where the tumor had been removed.
Our findings revealed that this new treatment, which we referred to as a nanogel, showcased excellent ability to load and release the drugs over a long period. We noted that it could effectively inhibit tumor growth post-surgery with minimal side effects, while maintaining the right balance of curcumin and TMZ throughout the treatment.
Overall, curcumin combined with TMZ in this specialized nanogel format presents a promising strategy to prevent the recurrence of resistant GBM after surgery. This innovative approach could pave the way for better patient outcomes in the future.
Our findings revealed that this new treatment, which we referred to as a nanogel, showcased excellent ability to load and release the drugs over a long period. We noted that it could effectively inhibit tumor growth post-surgery with minimal side effects, while maintaining the right balance of curcumin and TMZ throughout the treatment.
Overall, curcumin combined with TMZ in this specialized nanogel format presents a promising strategy to prevent the recurrence of resistant GBM after surgery. This innovative approach could pave the way for better patient outcomes in the future.
Read More
8
Tetrahydrocurcumin shows promise against glioblastoma
Synthesis, Cytotoxicity, and Mechanistic Evaluation of Tetrahydrocurcumin-Amino Acid Conjugates as LAT1-Targeting Anticancer Agents in C6 Glioma Cells.
Moderate relevance to turmeric effects.
We explored the potential of a turmeric derivative known as tetrahydrocurcumin (THC) in combating glioblastoma, a highly aggressive brain cancer. While THC on its own has shown promise, we aimed to enhance its effectiveness by modifying it to target a specific protein called LAT1, which plays a crucial role in how cancer cells acquire nutrients.
To test this, we synthesized a series of THC-amino acid conjugates, combining THC with several amino acids, like phenylalanine, in hopes of boosting its anticancer properties. Among these, THC conjugated with two phenylalanines stood out, demonstrating significantly increased toxicity towards glioma cells compared to THC alone. Specifically, we found that this compound not only killed more cancer cells, but also inhibited their growth and spread more effectively.
Interestingly, when we paired this modified THC with an LAT1 inhibitor, we observed even greater effects, leading to an increase in cellular death. This compound's mechanism involved shutting down cell-signaling pathways important for cancer cell survival. Overall, our findings suggest that THC, especially when modified, could serve as a promising option for treating brain tumors like glioblastoma, opening new avenues for therapeutic development.
To test this, we synthesized a series of THC-amino acid conjugates, combining THC with several amino acids, like phenylalanine, in hopes of boosting its anticancer properties. Among these, THC conjugated with two phenylalanines stood out, demonstrating significantly increased toxicity towards glioma cells compared to THC alone. Specifically, we found that this compound not only killed more cancer cells, but also inhibited their growth and spread more effectively.
Interestingly, when we paired this modified THC with an LAT1 inhibitor, we observed even greater effects, leading to an increase in cellular death. This compound's mechanism involved shutting down cell-signaling pathways important for cancer cell survival. Overall, our findings suggest that THC, especially when modified, could serve as a promising option for treating brain tumors like glioblastoma, opening new avenues for therapeutic development.
Read More
8
Insights on turmeric for brain tumors
Indian Ayurvedic medicine: Overview and application to brain cancer.
Moderate relevance to turmeric's effects
We looked into how turmeric might impact brain tumors, particularly through its key component, curcumin. The research gathered various studies that shed light on its potential benefits in fighting cancer.
In recent years, scientists have been keen on exploring turmeric's anti-cancer properties. They found that curcumin may help reduce cell growth in brain tumor cells, encourage apoptosis (or programmed cell death), and even inhibit certain pathways significant to cancer progression.
However, it’s essential to note that while initial findings show promise, more extensive testing in clinical trials is needed to truly understand turmeric’s effectiveness against brain tumors. Early results are encouraging, but we are still gathering evidence before we can confirm significant benefits.
Overall, it appears that turmeric, particularly through curcumin, may offer some anti-cancer activity against brain tumors. Yet, we must continue exploring its effects in more controlled settings to validate these observations.
In recent years, scientists have been keen on exploring turmeric's anti-cancer properties. They found that curcumin may help reduce cell growth in brain tumor cells, encourage apoptosis (or programmed cell death), and even inhibit certain pathways significant to cancer progression.
However, it’s essential to note that while initial findings show promise, more extensive testing in clinical trials is needed to truly understand turmeric’s effectiveness against brain tumors. Early results are encouraging, but we are still gathering evidence before we can confirm significant benefits.
Overall, it appears that turmeric, particularly through curcumin, may offer some anti-cancer activity against brain tumors. Yet, we must continue exploring its effects in more controlled settings to validate these observations.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.7
9.5
Effective treatment
I have been taking 2 gms (four capsules) of curcumin daily since my stage 4 breast cancer diagnosis a year ago. Remarkably, I entered remission within three months, and all tumours have disappeared. I have now been in remission with no evidence of disease for eight months.
9.5
Protects brain
This curcumin is one of the few effective supplements recommended for children with autism to alleviate neuroinflammation. It offers high purity and is safe for children. Curcumin’s anti-inflammatory effect is beneficial in protecting the brain from degenerative processes.
